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KMID : 0869619920090030188
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Journal of Korean Society of Hospital Pharmacists
1992 Volume.9 No. 3 p.188 ~ p.190
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Study on the relationship between the serum half-lives of amikacin and hematocrit in infectious patients
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Kwon Sung-Tack
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Abstract
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The relationship between t_(1/2) of amikacin and hematocrit was evaluated using the data from 30 inpatients of Seoul National University Hospital. Among them, 15 patients had a normal kidney function and the others had a impaired kidney function. There was a significant relationship between the t_(1/2) of amikacin and the reciprocal of hematocrit on both normal and impaired kidney function patients. The effect of hematocrit on t_(1/2) of amikacin might be due to the change in volume of distribution of amikacin. These findings might be clinically important in estimating dosage and dosing interval of amikacin for impaired kidney function patients.
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